Melatonin protects lung mitochondria from aging

Ciclopirox protects mitochondria from hydrogen peroxide toxicity.

1 The mitochondrial respiratory chain produces reactive oxygen species (ROS) during normal electron transport. Despite producing ROS, mitochondria are vulnerable to oxidative stress. Mitochondrial dysfunction has been associated with many degenerative diseases, making it important to identify compounds that protect mitochondria from ROS-mediated toxicity. Here we report that ciclopirox (CPX) bl...

P-11: Exogenous Melatonin Protects Follicogenesisand Endometrium from Apoptosis inFemale Mouse Treated with Nicotine

Background: Nicotine exposure causes impaired fertility , ovarian and uterus dysfunction. The pineal hormone melatonin is known as an antioxidant agent. The aim of this study was to investigate the possible protective role of exogen melatonin on altered ovary and endometrium with nicotine. Materials and Methods: Female adult NMRI mice were divided into four groups. The control group received ve...

O-13: Exogen Melatonin Protects SpermatogenicCells from Apoptosis in Mouse underChemotherapy

Background: The aim of this study was to investigate the possible protective role of melatonin on the apoptosis of germ cells in chemotherapy-induced spermiotoxicity. Materials and Methods: Male adult NMRI mice were divided into four groups. Then each group were divided into two subgroups of a and b. Group 1 (control): mice received vehicle (ethanol 1%) for 5 days; Group2 (Busulfan): mice recei...

How Melatonin Combats Aging

Melatonin, mitochondria, and cellular bioenergetics.

Aerobic cells use oxygen for the production of 90-95% of the total amount of ATP that they use. This amounts to about 40 kg ATP/day in an adult human. The synthesis of ATP via the mitochondrial respiratory chain is the result of electron transport across the electron transport chain coupled to oxidative phosphorylation. Although ideally all the oxygen should be reduced to water by a four-electr...